个人简历：

袁玲，女，特聘教授，博士生导师。2012-2018年，就读中国科学院遗传与发育生物学研究所，师从许执恒研究员，2018年博士毕业。长期从事神经发育及相关疾病致病机制的研究。以通讯作者与第一作者（含共同）发表研究工作于Science、PNAS（2篇）、PLoS Biology、EBioMedicine等期刊。荣获国家级青年人才、湖南省杰青、湖南省优青、湖湘青年英才、药康女科学家优秀青年等称号。相关成果入选“2017年度中国重大科学、技术和工程进展”，获得北京市自然科学一等奖、中国细胞生物学学会青年论文一等奖等。

研究方向

孤独症是一种常见的神经发育障碍疾病，患者的典型特征有社交异常，语言障碍以及刻板重复行为和兴趣狭窄。由于孤独症的高度临床和病因异质性，到目前为止，其发病机制仍不清楚，尚无治疗孤独症的有效方法。我们将围绕孤独症发病机制及防治这一核心问题，充分利用团队在基因改造小鼠模型及神经发育研究方面的优势，从基因功能、神经元活性和整体行为等不同层面，综合运用多学科研究方法和先进技术，系统研究孤独症的发病机制。

代表性论文

1. Chenjun Mu#, Pan Liu#, Liang Liu#, Yaqing Wang#, Kefu Liu, Xiangyu Li, Guozhong Li, Jianbo Cheng, Mengyao Bu, Han Chen, Manpei Tang, Yuanhang Yao, Jun Guan, Tiantian Ma, Zhengrong Zhou, Qingfeng Wu, Jiada Li, Hui Guo, Kun Xia, Zhengmao Hu, Xiaoqing Peng, Bing Lang, Faxiang Li, Xiaowei Chen, Zhiheng Xu*, Ling Yuan*, KCTD10 p.C124W variant contributes to schizophrenia by attenuating LLPS-mediated synapse formation, PNAS, 2024, doi:10.1073/pnas. 2400464121

2. Jianbo Cheng#, Zhen Wang#, Manpei Tang#, Wen Zhang#, Guozhong Li#, Senwei Tan, Chenjun Mu, Mengyuan Hu, Dan Zhang, Xiangbin Jia, Guozhong Li, Yangxuan Wen, Hui Guo, Dan Xu, Liang Liu, Jiada Li, Kun Xia, Faxiang Li, Ranhui Duan, Zhiheng Xu*, Ling Yuan*, KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13, PNAS, 2024, doi: 10.1073/pnas.2315707121

3. Zhen Miao#, Tian Tian#, Wei Chen#, Qianwen Wang#, Liang Ma#, Dan Zhang#, Min Xie#, Zijin Yu#, Xiya Guo, Genxiang Bai, Shaoli Zhao, Xi Chen, Wenyi Wang, Yizhou Gao, Shicheng Guo*, Ming Luo*, Ling Yuan*, Caihuan Tian*, Liang Wu*, Guangchuang Yu*, Dake Zhang*, Shiquan Sun*, Spatial resolved transcriptomics: Computational insights into gene transcription across tissue and organ architecture in diverse applications, The Innovation Life, 2024, 2(4): 100097

4. Ling Yuan#, Xingyao Huang#, Zhongyu Liu#, Feng Zhang#, Xingliang Zhu#, Jiuyang Yu#, Xue Ji, Yanpeng Xu, Guanghui Li, Cui Li, Hongjiang Wang, Yongqiang Deng, Menghua Wu, Mengli Cheng, Qing Ye, Dongyang Xie, Xiaofeng Li, Xiangxi Wang, Weifeng Shi, Baoyang Hu, Peiyong Shi, Zhiheng Xu*, Chengfeng Qin*, A Single Mutation in the prM Protein of Zika Virus Contributes to Fetal Microcephaly, Science, 2017, 358(6365): 933-936

5. Dan Xu#, Minghui Yao#, Yaqing Wang#, Ling Yuan#, Joerg D Hoeck#, Jingwen Yu, Liang Liu, Yvonne Y C Yeap, Weiya Zhang, Feng Zhang, Yinghang Feng, Tiantian Ma, Yujie Wang, Ng Dominic C H, Xiaoyin Niu, Bing Su, Axel Behrens*, Zhiheng Xu*, MEKK3 Coordinates with FBW7 to Regulate WDR62 Stability and Neurogenesis, PLoS Biology, 2018, 16(12): 0~e2006613