个人简历：

2012-2018年，就读中国科学院遗传与发育生物学研究所，师从许执恒研究员，2018年博士毕业。长期从事神经发育及相关疾病致病机制的研究。以通讯作者（含共同）与第一作者（含共同）身份在国际一流或主流杂志Science、PNAS、PloS Biology、EBioMedicine等期刊上发表多篇论文，还与国内外同行开展广泛合作研究，成果先后发表在Neuron、Cell Stem Cell、Nature Communications、Nano Letter、 Science Advances、J Clinical Investigation、 EbioMedicine等知名学术刊物。相关成果入选“2017年度中国重大科学、技术和工程进展”，并入围2017年度的“中国科学十大进展候选30项”。

研究方向：

孤独症是一种常见的神经发育障碍疾病，患者的典型特征有社交异常，语言障碍以及刻板重复行为和兴趣狭窄。由于孤独症的高度临床和病因异质性，到目前为止，其发病机制仍不清楚，尚无治疗孤独症的有效方法。我们将围绕孤独症发病机制及防治这一核心问题，充分利用团队在基因改造小鼠模型及神经发育研究方面的优势，从基因功能、神经元活性和整体行为等不同层面，综合运用多学科研究方法和先进技术，系统研究孤独症的发病机制。

代表性论文（#共同一作，*共同通讯）：

1.Jianbo Cheng#, Zhen Wang#, Manpei Tang#, Wen Zhang#, Guozhong Li#, Senwei Tan, Chenjun Mu, Mengyuan Hu, Dan Zhang, Xiangbin Jia, Yangxuan Wen, Hui Guo, Dan Xu, Liang Liu, Jiada Li, Kun Xia, Faxiang Li, Ranhui Duan, Zhiheng Xu*, Ling Yuan*, KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13, PNAS, 2024, doi: 10.1073/pnas.2315707121. (已接收, in press, 自然指数期刊，影响因子11.205).

2.Ling Yuan#, Xingyao Huang#, Zhongyu Liu#, Feng Zhang#, Xingliang Zhu#, Jiuyang Yu#, Xue Ji, Yanpeng Xu, Guanghui Li, Cui Li, Hongjiang Wang, Yongqiang Deng, Menghua Wu, Mengli Cheng, Qing Ye, Dongyang Xie, Xiaofeng Li, Xiangxi Wang, Weifeng Shi, Baoyang Hu, Peiyong Shi, Zhiheng Xu*, Chengfeng Qin*, A Single Mutation in the prM Protein of Zika Virus Contributes to Fetal Microcephaly, Science, 2017, 358(6365): 933-936

3.Dan Xu#, Minghui Yao#, Yaqing Wang#, Ling Yuan#, Joerg D Hoeck#, Jingwen Yu, Liang Liu, Yvonne Y C Yeap, Weiya Zhang, Feng Zhang, Yinghang Feng, Tiantian Ma, Yujie Wang, Ng Dominic C H, Xiaoyin Niu, Bing Su, Axel Behrens*, Zhiheng Xu*, MEKK3 Coordinates with FBW7 to Regulate WDR62 Stability and Neurogenesis, PLoS Biology, 2018, 16(12): 0~e2006613

4.Feng Zhang#, Hongjiang Wang#, Qin Wang#, Zhongyu Liu#, Ling Yuan#, Xingyao Huang#, Guanghui Li, Qing Ye, Haozhen Yang, Lei Shi, Yongqiang Deng, Chengfeng Qin*, Zhiheng Xu*, American Strain of Zika Virus Causes More Severe Microcephaly Than an Old Asian Strain in Neonatal Mice, EBioMedicine, 2017, 25: 95~105

5.Ling Yuan#, Ligui Xiong#, Tingting Deng, Yang Wu, Juan Li, Shuoqian Liu, Jianan Huang, Zhonghua Liu*, Comparative Profiling of Gene Expression in Camellia Sinensis L. Cultivar AnJiBaiCha Leaves during Periodic Albinism, Gene, 2015, 561(1): 23~29

6.Feng Zhang#, Dan Xu, Ling Yuan, Yiming Sun, Zhiheng Xu*, Epigenetic Regulation of Atrophin1 by Lysine-specific Demethylase 1 is Required for Cortical Progenitor Maintenance, Nature Communications, 2014, 5: 5815

7.Hongda Li#, Laura Saucedo-Cuevas, Ling Yuan, Danica Ross, Anide Johansen, Daniel Sands, Valentina Stanley, Alicia Guemez-Gamboa, Anne Gregor, Todd Evans, Shuibing Chen, Lei Tan, Henrik Molina, Nicholas Sheets, Sergey A. Shiryaev, Alexey V. Terskikh, Amy S. Gladfelter, Sujan Shresta, Zhiheng Xu, JosephG. Gleeson*, Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors, Neuron, 2019, 101(6): 1089-1098.e4

8.Chunfeng Li#, Xingliang Zhu#, Xue Ji#, Natalie Quanquin, Yongqiang Deng; Min Tian, Roghiyh Aliyari, Xiangyang Zuo, Ling Yuan, Shabbir Khan Afridi, Xiaofeng Li, Jae U. Jung, Nielsen-Saines Karin, Frank Xiaofeng Qin*, Chengfeng Qin*, Zhiheng Xu*, Genhong Cheng*, Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice , EBioMedicine, 2017, 24: 189~194

9.Ki-Jun Yoon#, Guang Song, Xuyu Qian, Jianbo Pan, Dan Xu, Hee-Sool Rho, Nam-Shik Kim, Christa Habela, Lily Zheng, Fadi Jacob, Feiran Zhang, Emily M. Lee, Weikai Huang, Francisca Rojas Ringeling, Caroline Vissers, Cui Li, Ling Yuan, Koeun Kang, Sunghan Kim, Junghoon Yeo, Yichen Cheng, Sheng Liu, Zhexing Wen, Chengfeng Qin, Qingfeng Wu, Kimberly M. Christian, Hengli Tang, Peng Jin, Zhiheng Xu, Jiang Qian, Heng Zhu, Hongjun Song, Guoli Ming*, Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins, Cell Stem Cell, 2017, 21(3): 349-358

10.Mingshu Zhang#, Zhifei Fu, Changqing Li, Anyuan Liu, Dingming Peng, Fudong Xue, Wenting He, Shan Gao, Fan Xu, Dan Xu, Ling Yuan, Fa Zhang, Zhiheng Xu, Tao Xu*, Pingyong Xu*, Fast Super-resolution Imaging Technique and Immediate Early Nanostructure Capturing by a Photo-convertible Fluorescent Protein, Nano Lett, 2019,https://doi.org/10.1021/acs.nanolett.9b02855

11.Yiqiang Zhi, Xiaokun Zhou, Jurui Yu, Ling Yuan, Hongsheng Zhang, DominiC. H. Ng, Zhiheng Xu, Dan Xu*, Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases, Front. Cell Dev. Biol., 2021,https://doi.org/10.3389/fcell.2021.640753

12.Dama Faniriantsoa Henrio Marcellin, Limin Guo, Haiyang Yu, Shuchao Wang, Paul Pielnaa, Adonira Saro, Ismail Bilal Masokano, Malik Muhammad Adil, Ling Yuan, Yanxia Huang, Deyang Cai, Ruping Zheng, Zhongjun Huang, Aixiang Luo, Cyrollah Disoma, Pinjia Liu, Zanxian Xia*, Jufang Huang*, Zika Virus and Its Association with Neurological Disorders, Advances in Microbiology, 2022, DOI: 10.4236/aim.2022.124016

13.Xiaokun Zhou, Wenxiang Yi, Yiqiang Zhi, Jurui Yu, Danping Lu, Zhousong Luo, Ling Yuan, Liyu Chen, Zhiheng Xu*, Dan Xu*, Stress‑Activated Protein Kinase JNK Modulates Depression‑like Behaviors in Mice, Molecular Neurobiology, 2023, doi: 10.1007/s12035-023-03209-x

14.Guodong Chen#, Bin Yu#, Senwei Tan#, Jieqiong Tan#, Xiangbin Jia, Qiumeng Zhang, Xiaolei Zhang, Qian Jiang, Yue Hua,Yaoling Han, Shengjie Luo, Kendra Hoekzema, Raphael A. Bernier, Rachel K. Earl, Evangeline C. Kurtz-Nelson, Michaela J. Idleburg, Suneeta Madan-Khetarpal, Rebecca Clark, Jessica Sebastian, Alberto Fernandez-Jaen, Sara Alvarez, Staci D. King, Luiza L.P. Ramos, Mara Lucia S.F. Santos, Donna M. Martin, Dan Brooks, Joseph D. Symonds, Ioana Cutcutache, Qian Pan, Zhengmao Hu, Ling Yuan, Evan E. Eichler, Kun Xia, Hui Guo, GIGYF1 disruption associates with autism and impaired IGF-1R signaling, J Clin Invest., 2022, 132(19):e159806

15.Xiangbin Jia#, Shujie Zhang#, Senwei Tan#, Bing Du, Mei He, Haisong Qin, Jia Chen, Xinyu Duan, Jingsi Luo, Fei Chen, Luping Ouyang, Jian Wang, Guodong Chen, Bin Yu, Ge Zhang, Zimin Zhang, Yongqing Lyu, Yi Huang, Jian Jiao, Jin Yun (Helen) Chen, Kathryn J. Swoboda, Emanuele Agolini, Antonio Novelli, Chiara Leoni, Giuseppe Zampino, Gerarda Cappuccio, Nicola Brunetti-Pierri, Benedicte Gerard, Emmanuelle Ginglinger, Julie Richer, Hugh McMillan, Alexandre White-Brown, Kendra Hoekzema, Raphael A. Bernier, Evangeline C. Kurtz-Nelson, Rachel K. Earl, Claartje Meddens, Marielle Alders, Meredith Fuchs, Roseline Caumes, Perrine Brunelle, Thomas Smol, Ryan Kuehl, Debra-Lynn Day-Salvatore, Kristin G. Monaghan, Michelle M. Morrow, Evan E. Eichler, Zhengmao Hu, Ling Yuan, Jieqiong Tan, Kun Xia*, Yiping Shen*, Hui Guo*, De novo variants in genes regulating stress granule assembly associate with neurodevelopmental disorders, Sci. Adv., 2022, 8, eabo7112