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地 址：湖南省长沙市岳麓区桐梓坡路172号

个人简介

1998.9-2002.6 湖南师范大学生命科学学院生物科学专业，理学学士

2002.9-2005.6 湖南师范大学生命科学学院发育生物学专业，理学硕士

2005.9-2008.8 湖南师范大学生命科学学院发育生物学专业，理学博士

工作经历

2008.7-2014.8 中南大学生命科学学院细胞生物学系，讲师

2014.9-至今 中南大学生命科学学院细胞生物学系，副教授

研究方向

水产生物天然免疫及抗感染机制、骨发育机理

研究简介

研究领域主要集中在水产生物天然免疫调控机制及育种应用研究。（合作）主持国家自然科学基金（青年No. 31201984及地区No. 31760756），湖南省自然科学基金（青年No. 14JJ3047及面上No. 2018JJ2495）及国家、省重点实验室开放课题(No. 2019KF007、No. 2018TP1027)等6项。发表SCI论文20余篇，参与申请并授权国家发明专利5项。

1. 水产动物天然免疫相关miRNAs功能及调控机制研究。miRNAs是一类内源性的短链非编码RNA分子，由22个核苷酸构成的功能调节因子，对组织器官发育、干细胞分化、免疫系统功能、肿瘤发生等几乎所有生物学过程都有调控作用。研究发现，miRNAs在复杂的宿主与病原的相互作用网络中发挥重要的调节作用。我们将采用新一代测序技术来全面筛选和鉴定团头鲂miRNAs，发掘其免疫功能，体内外阐明其免疫防御的分子调控机理。

2. 水产动物天然免疫相关基因功能及调控机制研究。采用转录组测序和克隆技术获得团头鲂天然免疫相关的候选基因，对其免疫功能进行深入探讨。同时，对候选基因进行SNPs分型及性状关联分析，获得功能性SNPs位点，为抗病分子标记辅助育种奠定理论基础。

3. 骨发育过程中的表观遗传调控机理研究。长链非编码RNA（lncRNAs）是一类转录本长度超过200 nt的不编码蛋白的RNA分子，在多种层面调控基因表达。利用RNA-sequence技术获得与骨发育密切相关的lncRNAs，从细胞和机体水平探究lncRNAs在骨发育中的作用，进一步诠释其表观调控机制。

代表论文（*通讯作者）

1. Lv YN, Xu Q, Mao Y, Xu YD, Zhang R, Zhong H, Zhou Y, Xiao J, Du MK, Song HY, Liang YH,Yan JP*. TRAF3 of blunt snout bream participates in host innate immune response to pathogenic bacteria via NF-κB signaling pathway. Fish Shellfish Immunol, 2020, 104:592-604.

2. Jiang YH, Mao Y, Lv YN, Tang LL, Zhou Y, Zhong H, Xiao J,Yan JP*. Natural resistance associated macrophage protein Is involved in immune response of blunt snout bream,Megalobrama amblycephala. Cells, 2018, 7(4): pii:E27.

3. Lv YN, Xiang XY, Jiang YH, Tang LL, Zhou Y, Zhong H, Xiao J,Yan JP*. Identification and characterization of lipopolysaccharide induced TNFα factor from blunt snout bream,Megalobrama amblycephala. Int J Mol Sci, 2017, 18(2): pii:E233.

4. Tang LL, Xiang XY, Jiang YH, Lv YN, Zhou Y, Zhong H, Xiao J, Zhang YF, Jiang HY,Yan JP*. Identification and characterization of a novel Toll-like receptor 4 homologue in blunt snout bream,Megalobrama amblycephala. Fish Shellfish Immunol, 2016, 57:25-34.

5. Jiang YH, Tang LL, Zhang YF, Jiang HY, Liu XW, Yang LY, Zhang L, Mao JR,Yan JP*. Identification and characterization of immune-related microRNAs in blunt snout bream,Megalobrama amblycephala. Fish Shellfish Immunol, 2016, 49:470-92.

6. Tang LL, Liang YH, Jiang YH, Liu SJ, Zhang FY, He X, Wang TY, Zhou Y, Zhong H,Yan JP*. Identification and expression analysis on bactericidal permeability-increasing protein/lipopolysaccharide-binding protein of blunt snout bream,Megalobramaamblycephala. Fish Shellfish Immunol, 2015, 45:630-40.

7. Han ZJ, Zhou Y, Zhang XJ,Yan JP, Xiao J, Luo YJ, Zheng HF, Zhong H. Ghrelin modulates the immune response and increases resistance to Aeromonas hydrophila infection in hybrid tilapia. Fish Shellfish Immunol, 2020, 98:100-108.

8. Zhong H, Zhang XJ, Xu Q,Yan JP,Han ZJ, Zheng HF, Xiao J, Tang ZY, Wang FH, Luo YJ, Zhou Y. Nonadditive and Asymmetric Allelic Expression of Growth Hormone in Hybrid Tilapia. Front Genet, 2019, 10: 961.

9. Zhou Y, Zhang XJ, Xu Q,Yan JP, Yu F, Wang, FH, Xiao, J, Luo, YJ, Zhong H. Nonadditive and allele-specific expression of insulin-like growth factor 1 in Nile tilapia (Oreochromis niloticus, female) x blue tilapia (O. aureus, male) hybrids. Comp Biochem Phys B, 2019, 232:93-100.

10. Qu FF, Tang JZ, Peng XY, Zhang H, Shi LP, Huang ZZ, Xu WQ, Chen HQ, Shen Y,Yan JP, Li JZ, Lu SQ, Liu Z. Two novel MKKs (MKK4 and MKK7) fromCtenopharyngodon idellaare involved in the intestinal immune response to bacterial muramyl dipeptide challenge. Dev Comp Immunol, 2019, 93:103-14.

11. Zhou Y, Zhang XJ, Xu Q,Yan JP, Yu F, Xiao J, Guo ZB, Luo, YJ, Zhong H. Nonadditive expression of lipid metabolism pathway-related genes in intestine of hybrids of Nile tilapia females (Oreochromis niloticus) and blue tilapia males (Oreochromis aureus). Mol Biol Rep, 2019, 46: 425-32.

12. Zhong H, Zhang H, Tang ZY, Guo ZB,Yan JP, Xiao J, Luo, YJ, Zhou Y. Evidence for natural selection of immune genes fromParachromis managuensisby transcriptome sequencing. Biotechnol Biotec Eq, 2018, 32: 1431-39.

13. Hu R, Qu FF, Tang JZ, Zhao Q,Yan JP, Zhou ZG, Zhou Y, Liu Z. Cloning, expr-

ession, and nutritional regulation of the glutamine synthetase gene inCtenoph-aryngodon idellus. Comp Biochem Physiol B Biochem Mol Biol, 2017, 212: 70-6.

14.Yu F, Yu JH, Zhou Y,Yan JP, Fang YH, Wang WJ, Yang Z. Phylogenetic study of Ameiurus melas based on complete mitochondrial DNA sequence. Mitochondrial DNA A DNA Mapp Seq Anal. 2016, 27(6):4706-07.

15. Zhou Y, Zhong H, Xiao J, Yan JP, Luo YJ, Gan X, Yu F. Identification and comparative analysis of piRNAs in ovary and testis of Nile tilapia (Oreochromis niloticus). Genes Genom, 2016, 38: 519-27.

16.Yan JP, Liu LG, Liu SJ, Guo XH, Liu Y. Comparative analysis of mitochondrial control region in polyploid hybrids of red crucian carp (Carassius auratus) × blunt snout bream (Megalobrama amblycephala). Fish Physiol Biochem, 2010, 36: 263-72.

17. Guo XH,Yan JP(Co-first-authors), Liu SJ, Xiang B, Liu Y. Isolation and expression analyses of the Sox9a gene in triploid crucian carp. Fish Physiol Biochem, 2010, 36: 125-33.

18. Liu LG,Yan JP(Co-first-authors), Liu SJ, Liu D, You CP, Zhong H, Tao M, Liu Y. Evolutionary analysis of allotetraploid hybrids of red crucian carp × common carp, based on ISSR, AFLP molecular markers and cloning of cyclins genes. Chinese Sci Bull, 2009, 54: 2849-61.

19.Yan JP, Guo XH, Liu SJ,Xiao J, Liu Z, Chen YB, Liu Y. Maternal inheritance in polyploid fish inferred from mitochondrial ATPase genes analysis. Prog Nat Sci, 2009, 19: 693-98.

20.Yan JP, Liu SJ, Sun YD, Zhang C, Luo KK, Liu Y.RAPD and microsatellite analysis of diploid gynogens fromallotetraploid hybrids of red crucian carp (Carassius auratus) x common carp (Cyprinus carpio). Aquaculture, 2005, 243: 49-60.

21. Liu SJ, Qin QB, Xiao J, Lu WT, Shen JM, Li W, Liu JF, Duan W, Zhang C, Tao M, Zhao RR,Yan JP, Liu Y. The Formation of the Polyploid Hybrids From Different Subfamily Fish Crossings and Its Evolutionary Significance. Genetics, 2007, 176: 1023-34.