研究方向

李星，博士，副教授，博士生导师，硕士生导师。

自2012年攻读博士学位近十年来主要从事脊髓损伤修复与神经再生研究，通过解析脊髓损伤急性和陈旧性微环境，挖掘和验证影响轴突再生、神经环路重建和功能恢复的调控机制并设计和制备相关药物和/或干细胞修饰的生物支架材料，构建大小鼠、比格犬及恒河猴等动物脊髓损伤模型，开发具有临床转化潜力的修复方案。

具体研究方向包括：

1. 脊髓损伤后多组学解析损伤微环境挖掘神经再生相关机制。深度剖析和刻画脊髓损伤后的微环境动态组成及变化，深刻认识和精确描述损伤抑制微环境的特性，寻找调控神经再生与功能修复的新干预靶标。

2. 脊髓损伤后内源性神经发生与神经环路重建和功能再生。制备和建立多种谱系示踪小鼠模型，对响应脊髓损伤而动员的内源神经干细胞的激活、定向分化、成熟及功能化等相关进程及其机制进行研究。最终实现高效调控和利用内源性神经干细胞进行脊髓损伤修复的目的。

3. 制备功能支架材料修复脊髓损伤。依据1和2中获取的上游信息，设计和制备可修复脊髓损伤的生物支架材料，筛选和优化得到在空间和时间上实现顺序梯度等精确给药的功能支架，实现损伤后神经再生，环路重建和功能修复。

主持科研项目

1. 国家自然科学基金委员会，面上项目，82271429，2023.01-2026.12，52万，主持

2. 中国科学院A类战略性先导科技专项，XDA16040704，2021.9-2023.12，240万，主持

3. 国家自然科学基金委员会，面上项目，82071398，2021.01-2024.12，55万，主持

4. 中国科学院A类战略性先导科技专项，XDA16040601，2020.01-2021.12，202万，主持

5. 中国科学院A类战略性先导科技专项，XDA16040704，2020.10-2021.12，60万，主持

6. 博士后创新人才支持计划项目，BX201600190，2016.09-2018.08，20万，主持

代表性论文（*通讯作者，^#共同第一作者）

1. Yin W. ^#, Xue W. ^#, Zhu H., Shen H., Xiao Z., Wu S., Zhao Y., Cao Y., Tan J., Li J., Liu W., Wang L., Meng L., Chen B., Zhao M., Jiang X.*, Li X.*, Ren C.*, and Dai J*. (2021) Scar tissue removal-activated endogenous neural stem cells aid Taxol-modified collagen scaffolds in repairing chronic long-distance transected spinal cord injury. Biomaterials Science. 2021 Jul 7;9(13):4778-4792.

2. Liu D.^#, Shen H.^#, Shen Y., Long G., He X., Zhao Y., Yang Z., Dai J.^* and Li X.* (2021) Dual-Cues Laden Scaffold Facilitates Neurovascular Regeneration and Motor Functional Recovery After Complete Spinal Cord Injury. Advanced Healthcare Materials. 2021 May;10(10): e2100089.

3. Liu D., Shu M., Liu W., Shen Y., Long G., Zhao Y., Hou X., Xiao Z., Dai J.^* and Li X.* (2021) Binary scaffold facilitates in situ regeneration of axons and neurons for complete spinal cord injury repair. Biomaterials Science. 21;9(8):2955-2971.

4. Long G., Liu D., He X., Shen Y., Zhao Y., Hou X., Chen B., OuYang W.^*, Dai J.^* and Li X.* (2020) A dual functional collagen scaffold coordinates angiogenesis and inflammation for diabetic wound healing. Biomaterials Science. 21;8(22):6337-6349.

5. Liu D., Li X.*, Xiao Z., Yin W., Zhao Y., Tan J., Chen B., Jiang X.*, Dai J*. (2019) Different functional bio-scaffolds share similar neurological mechanism to promote locomotor recovery of canines with complete spinal cord injury. Biomaterials. 214:119230.

6. Li X.^#, Liu S.^#, Zhao Y.^#, Li J., Ding W., Han S., Chen B., Xiao Z., Dai J. (2016) Training neural stem cells on functional collagen scaffolds for severe spinal cord injury repair. Advanced Functional Materials. 26, 5835–5847.

7. Li X.^#, Liu D.^#, Xiao Z.^#, Zhao Y., Han S., Chen B., Dai J. (2019) Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation. Biomaterials. 197:20-31.

8. Li X.^#, Zhao Y.^#, Cheng S.^#, Han S., Shu M., Chen B., Chen X., Tang F., Wang N., Tu Y., Wang B., Xiao Z., Zhang S., and Dai J. (2017) Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenous neural stem cells for acute spinal cord injury repair. Biomaterials. 137, 73-86.

9. Li X.^#, Han J.^#, Zhao Y., Ding W., Wei J., Han S., Shang X., Wang B., Chen B., Xiao Z., Dai J. (2015). Functionalized collagen scaffold neutralizing the myelin inhibitory molecules promoted neurite outgrowth in vitro and facilitated spinal cord regeneration in vivo. ACS Applied Materials and Interfaces, 7 (25) 13960–13971.

10. Li X.^#, Han J.^#, Zhao Y., Ding W., Wei J., Han S., Shang X., Wang B., Chen B., Xiao Z. Dai J. (2016) Functionalized collagen scaffold implantation and cAMP administration collectively facilitate spinal cord regeneration. Acta Biomaterialia. 15 (30) 233-45.

11. Li X., Dai J. (2017) Bridging the gap with functional collagen scaffolds: tuning endogenous neural stem cells for severe spinal cord injury repair. Biomaterials Science. 6, 265-271.

12. Li X.^#, Yang B.^#, Xiao Z., Zhao Y., Han S., Yin Y., Chen B., Dai J. (2018) Comparison of subacute and chronic scar tissues after complete spinal cord transection. Experimental Neurology.16 (306):132-137.

13. Li X.^#, Tan J.^#, Xiao Z^#., Zhao Y., Han S., Liu D., Yin W., Li J., Li J., Wanggou S., Chen B., Ren C., Jiang X., Dai J. (2017) Transplantation of hUC-MSCs seeded collagen scaffolds reduces scar formation and promotes functional recovery in canines with chronic spinal cord injury. Scientific Reports. 7, 43559.

14. Li X.^#, Ma D.^#, Chen J.^#, Pu G., Ji Y., Lei C., Du Z., Liu B., Ye H., Wang H. (2012) Biochemical characterization and identification of a cinnamyl alcohol dehydrogenase from Artemisia annua. Plant Science, 193–194 (2012) 85–95.

15. Fan C.^#, Li X.^#, Xiao Z., Zhao Y., Liang H., Wang B., Han S., Li X., Xu B., Wang N., Liu S., Xue W., Dai J. (2017) A modified collagen scaffold facilitates endogenous neurogenesis for acute spinal cord injury repair. Acta Biomaterialia. 51, 304-316.

16. Yin W. ^#, Li X.^#, Zhao Y., Tan J., Wu S., Cao Y., Li J., and Dai J. (2018) Taxol-modified collagen scaffolds implantation promotes functional recovery after long-distance spinal cord complete transection in canines. Biomaterials Science. 6(5):1099-1108.

17. Shen H.^#, Chen X.^#, Li X.^#, Jia K., Xiao Z., and Dai J. (2019) Transplantation of adult spinal cord grafts into spinal cord transected rats improves their locomotor function. Sci China Life Sci. DOI:10.1007/s11427-019-9490-8.

18. Han S.^#, Xiao Z.^#, Li X.^#, Zhao, H., Wang, B., Qiu, Z., Li, Z., Mei, X., Xu, B., Fan, C., Chen, B., Han,J., Gu, Y., Yang, H., Shi, Q., Dai, J. (2017). Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine. Sci China Life Sci. 61, 2-13.

19. Han S.^#, Li X.^#, Xiao, Z.^#, Dai, J. (2017). Complete canine spinal cord transection model: a large animal model for the translational research of spinal cord regeneration. Sci China Life Sci. 61, 115-117.

20. Han S.^#, Yin W.^#, Li X.^#, Wu S., Cao Y., Tan J., Zhao Y., Hou X., Wang L., Ren C., Li J., Hu X., Mao Y., Li G., Li B., Zhang H., Han J., Chen B., Xiao Z., Jiang X., and Dai J. (2019) Pre-Clinical Evaluation of CBD-NT3 Modified Collagen Scaffolds in Completely Spinal Cord Transected Non-Human Primates. Journal of Neurotrauma 36:1–9 DOI: 10.1089/neu.2018.6078.

21. Shen Y.^#, Li X.^#, Chai T., Wang H. (2016) Outer phere residues influence the catalytic activity of a chalcone synthase from Polygonum cuspidatum. FEBS Open Bio. 6, 610-618.

专利

1.  王红，李星，马东明，陈建林。具有肉桂醇脱氢酶活性的蛋白及其编码基因与应用。专利号：CN102344915 B。

2.  王红，冀云鹏，马东明，郝鹤，李星。青蒿bHLH转录因子及其编码基因与应用。专利号：CN102372769 A。

3.  戴建武，赵燕南，陈冰，肖志峰，韩素芳，李星。降解速率可控的引导神经再生的功能材料及其制备方法与应用。专利号：CN105497979 A。

4.  戴建武, 陈曦, 李星, 肖志峰, 赵燕南, 陈冰, 侯祥林, 胡慧霞. 一种复合支架材料及其应用. 专利号：CN110183536A。