研究方向

李星，博士，教授，博士生导师，入选中南大学升华学者优秀青年岗位。现任中国医师协会神经修复学专业委员会委员，湖南省生物化学与分子生物学学会青年委员。主要从事脊髓损伤修复与神经再生研究，通过解析脊髓损伤急性和慢性微环境，挖掘和验证影响轴突再生、神经环路重建和功能恢复的调控机制并设计和制备相关药物和/或干细胞修饰的生物支架材料，构建大小鼠、比格犬及恒河猴等动物脊髓损伤模型，开发具有临床转化潜力的修复方案。近年来主持国家自然科学基金面上项目3项，湖南省优秀青年基金项目1项，中国科学院A类战略性先导科技专项外协任务多项，曾获首届博士后创新人才支持计划项目支持。

李星课题组研究方向包括：

1.脊髓损伤后多组学解析损伤微环境挖掘神经再生相关机制。深度剖析和刻画脊髓损伤后的微环境动态组成及变化，深刻认识和精确描述损伤抑制微环境的特性，寻找调控神经再生与功能修复的新干预靶标。

2.脊髓损伤后内源性神经发生与神经环路重建和功能再生。制备和建立多种谱系示踪小鼠模型，对响应脊髓损伤而动员的内源神经干细胞的激活、定向分化、成熟及功能化等相关进程及其机制进行研究。最终实现高效调控和利用内源性神经干细胞进行脊髓损伤修复的目的。

3.制备功能支架材料修复脊髓损伤。设计和制备可修复脊髓损伤的生物支架材料，筛选和优化得到在空间和时间上实现顺序梯度等精确给药的功能支架，实现损伤后神经再生，环路重建和功能修复。

近年代表性论文

1.Ma W., Kong Y., Sheng X., Liu T., Zhang K., Wen R., Liu D., Long G.*, and Li X.*. (2025) A hydrogel-based nanoparticles sustained-release system selectively targeting pro-inflammatory microglia for spinal cord injury repair.Journal of Controlled Release.387:114180.

2.Zhang K., WenR., Ma W., He X., Yang Z., Liu D.* and Li X.*. (2025) Neuronal Dual-Specificity Phosphatase 26 Inhibition via Reactive-Oxygen-Species Responsive Mesoporous-Silica-Loaded Hydrogel for Spinal Cord Injury Repair.ACSNano.4;19(4):4942-4958.

3.WenR.^#, Long G.^#, He X.^#, Zhang K., Ma W., Shen Y., Xiao Z., Zhao Y., Liu D.*, Dai J.* and Li X.*. (2025) Revisiting the unobtrusive role of exogenous stem cells beyond neural circuits replacement in spinal cord injury repair.Theranostics.15(4): 1552-1569.

4.Liu D.^#, Shen H.^#, Zhang K.^#, Shen Y., Wen R., He X., Long G., and Li X.*. (2024) Functional Hydrogel Co-Remolding Migration and Differentiation Microenvironment for Severe Spinal Cord Injury Repair.Advanced Healthcare Materials.2024 Nov 7:e2301662.

5.Xu B.^#, Liu D.^#, Liu W.^#, Long G., Liu W., Wu Y., He X., Shen Y., Jiang P., Yin M., Fan Y., Shen H., Shi L., Zhang Q., Xue W., Jin C., Chen Z., Chen B., Li J., Hu Y.,Li X.*, Xiao Z.*, Zhao Y.*, and Dai J*. (2023) Engineered human spinal cord-like tissues with dorsal and ventral neuronal progenitors for spinal cord injury repair in rats and monkeys.Bioactive Materials.2023 Mar 29:27:125-137.

6.Li X.^#,Zhao Y.^#, Cheng S.^#,Han S., Shu M., Chen B., Chen X., Tang F., Wang N., Tu Y., Wang B., Xiao Z., Zhang S., and Dai J. (2017) Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenous neural stem cells for acute spinal cord injury repair.Biomaterials. 137, 73-86.

7.Li X.^#, Liu S.^#, Zhao Y.^#, Li J., Ding W., Han S., Chen B., Xiao Z., Dai J. (2016) Training neural stem cells on functional collagen scaffolds for severe spinal cord injury repair.Advanced Functional Materials. 26, 5835–5847.