个人简介
虢毅,女,博士,教授,硕士生导师。1998年于湖南大学化学化工学院获得学士学位,2002年于中南大学医药信息系获得硕士学位,2012年于中南大学基础医学院生理学系获得博士学位,2015-2017年在美国MD Anderson Cancer Center白血病系任研究助理,2013年在中南大学晋升为副教授,2020年在中南大学晋升为教授。
其研究获得多项国家自然科学基金、教育部高等学校博士学科点专项科研基金、湖南省自然科学基金的资助,在Proc Natl Acad Sci USA、Ann Neurol、Cancer Res、PLoS Genet、Neurology、Arch Neurol、BBRC和Mov Disord等国际知名刊物发表SCI论文63篇(其中第一作者或通讯作者28篇),研究成果获2015年全国首届妇幼健康科学技术奖一等奖(排名第四)、2015年第十二届湖南医学科技奖一等奖(排名第三),2016年湖南省科学技术奖自然科学奖三等奖(排名第三)及2017年辽宁省科技进步奖一等奖(排名第七)。目前已获得一项发明专利(已公开),另参加国际、国内学术交流多次,发表会议期刊论文多篇。
主要研究方向:各种遗传性疾病的基因定位、基因克隆、致病位点鉴定、易感基因筛选和生物信息学研究工作,在遗传机制研究方面有较好的基础,研究团队已鉴定300多个遗传病家系致病基因突变。
代表性成果:(#并列第一作者,*通讯作者)
1.Yunyun Gao, Liyue Gong, Hao Liu, Yi Kong, Xusheng Wu, Yi Guo*(共同通讯作者), DeHua Hu*, Research on the influencing factors of users' information processing in online health communities based on Heuristic-Systematic Model[J]. Frontiers in Psychology. 2022;13:966033.
2.Lihong Peng, Hao Jiang, Yi Guo*(共同通讯作者), Dehua Hu*. Effect of Information Framing on Wearing Masks During the COVID-19 Pandemic: Interaction With Social Norms and Information Credibility[J]. Front Public Health. 2022;10:811792.
3.Yi Kong; Hao Jiang; Zhisheng Liu; Yi Guo*(共同通讯作者); Dehua Hu*. The Uptake and Vaccination willingness of COVID-19 Vaccine among Chinese Residents: Web-Based 0nline Cross-Sectional Study[J]. Vaccines, 2022, 10(1): 90.
4.Liyue Gong, Hao Jiang, Xusheng Wu, Yi Kong, Yunyun Gao, Hao Liu, Yi Guo*(共同通讯作者), Dehua Hu*. Exploring users’health behavior changes in online health communities: Heuristic-Systematic perspective study[J]. International Journal of Environmental Research and Public Health. 2022; 19(18):11783.
5.Yuan, Meng, Yi Guo#(并列第一作者), Hong Xia, Hongbo Xu, Hao Deng, Lamei Yuan. Novel SCN5A and GPD1L Variants identified in two unrelated Han-Chinese patients with clinically suspected Brugada Syndrome. Frontiers Cardiovascular Medicine. 2021, 8: 758903
6.Yi Guo(第一作者), Yan Sun, Zhi Song, Wen Zheng, Wei Xiong, Yan Yang, Lamei Yuan, Hao Deng. Genetic analysis and literature review of SNCA variants in Parkinson's disease. Front Aging Neurosci. 2021, 13:648151.
7.Yi Guo (第一作者), Peng Wang, Xiaorong Li, Shaihong Zhu, Hongbo Xu, Shizhou Li, Hao Deng, Lamei Yuan. Identifying a BRCA2 c.5722_5723del mutation in a Han-Chinese family with breast cancer. Bioscience Reports. 2019, 39(4).pii: BSR20182471.
8.Heng Xiao#, Yi Guo#(并列第一作者), Junhui Yi, Hong Xia, Hongbo Xu, Lamei Yuan, Pengzhi Hu, Zhijian Yang, Zhenghao He, Hongwei Lu, Hao Deng, Identification of a novel keratin 9 missense mutation in a Chinese family with epidermolytic palmoplantar keratoderma, Cell Physiol Biochem, 2018, 46(5): 1919-1929 9.Yi Guo(第一作者), Ting Tan, Xiong Deng, Zhi Song, Zhijian Yang, Yan Yang, Hao Deng, TCEANC2 rs10788972 and rs12046178 variants in the PARK10 region in Chinese Han patients with sporadic Parkinson's disease, Neurobiology of Aging, 2015, 36(12): 3335.e1-2
10.Yi Guo (第一作者), Weidong Le, Joseph Jankovic, Huarong Yang, Hongbo Xu, Wenjie Xie, Zhi Song, Hao Deng, Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease, Mov Disord, 2011, 26(9): 1729-1732