个人简历

教育经历

2009/9-2015/6 中国科学技术大学，遗传学，博士

2005/9-2009/6 中南大学，生物科学，学士

工作经历：

2015/7-2022/8 中信湘雅生殖与遗传专科医院，副研究员

2022/9-至今 中南大学生命科学学院，特聘副教授

研究经历

遗传学博士，博士生/硕士生导师。湖南省杰青，湖湘青年英才支持计划获得者。课题组重点关注我国育龄夫妇不孕不育率逐年攀升的社会现状，聚焦辅助生殖技术（试管婴儿）治疗不孕症过程中胚胎发育停滞频发的临床难题，通过高通量测序技术，基于生物信息学分析，挖掘潜在的致病基因/变异，并结合细胞及小鼠模型，深入研究其致病机理，为不孕不育的精准诊疗提供理论依据。先后主持国家自然科学基金面上和青年项目，中国博士后科学基金特别资助和面上项目、湖南省及长沙市自然科学基金项目等10余项资助；以第一作者/通讯作者（含共同）在The American Journal of Human Genetics（2篇），Nature communications（2篇）， EMBO Molecular Medicine（2篇）及Human Reproduction等国际生殖及遗传领域权威杂志发表SCI论文20余篇。

研究方向

1、植入前胚胎发育停滞的遗传病因学研究

2、植入前胚胎质量的无创预警模型构建

代表性论文（*第一作者，#通讯作者）

1.Zheng W^*, Zhou Z^*, Sha Q^*, Niu X^*, Sun X^*, Shi J^*, Zhao L, Zhang S, Dai J, Cai S, Meng F, Hu L, Gong F, Li X, Fu J, Shi R, Lu G, Chen B, Fan H, Wang L, Sang Q^#, Lin G^#. (2020) Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility. Am J Hum Genet 107: 24-33

2.Sha Q-Q^*, Zheng W^*, Wu Y-W, Li S, Guo L, Zhang S, Lin G^#, Ou X-H^#, Fan H-Y^#(2020) Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans. Nat Commun 11: 4917

3.Zhang YL^*, Zheng W^*, Ren P, Hu H, Tong X, Zhang SP, Li X, Wang H, Jiang JC, Jin J, Yang W, Cao L, He Y, Ma Y, Zhang Y, Gu Y, Hu L, Luo K, Gong F, Lu GX, Lin G^#, Fan H-Y^#, Zhang SY^#. (2021) Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation.EMBO Mol Med13: e14887

4.Dai J^*, Zhang T^*, Guo J, Zhou Q, Gu Y, Zhang J, Hu L, Zong Y, Song J, Zhang S, Dai C, Gong F, Lu G, Zheng W^#, Lin G^#(2021) Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice. Am J Hum Genet 108: 469-481

5.Dai J^*, Li Q^*, Zhou Q, Zhang S, Chen J, Wang Y, Guo J, Gu Y, Gong F, Tan Y, Lu G, Zheng W^#, Lin G^#(2022) IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect. EMBO Mol Med 14: e16501

6.Wu Y-W^*, Li S^*, Zheng W^*, Li Y-C^*, Chen L, Zhou Y, Deng Z-Q, Lin G, Fan H-Y^#, Sha Q-Q^#(2022) Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging. Nat Commun 13: 3191

7.Zhang Y-L^*, Zheng W^*, Ren P^*, Jin J, Hu Z, Liu Q, Fan H-Y, Gong F, Lu G-X, Lin G^#, Zhang S^#, Tong X^#(2022) Biallelic variants in MOS cause large polar body in oocyte and human female infertility. Hum Reprod 37: 1932-1944

8.Zheng W^*, Sha QQ^*, Hu H, Meng F, Zhou Q, Chen X, Zhang S, Gu Y, Yan X, Zhao L, Zong Y, Hu L, Gong F, Lu G, Fan HY^#, Lin G^#(2022) Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest. J Med Genet 59: 850-857

9.Dai J^*, Chen Y^*, Li Q, Zhang T, Zhou Q, Gong F, Lu G, Zheng W^#, Lin G^#(2022) Pathogenic variant in ACTL7A causes severe teratozoospermia characterized by bubble-shaped acrosomes and male infertility. Mol Hum Reprod 28

10.Wang J^*, Zheng W^*, Zhang S^*, Yan K, Jin M, Hu H, Ma Z, Gong F, Lu G, Ren Y, Lin L, Lin G, Hu L^#, Liu S^#(2021) An increase of phosphatidylcholines in follicular fluid implies attenuation of embryo quality on day 3 post-fertilization. BMC Biol 19: 200

11.Zheng W^*, Hu H^*, Zhang S, Xu X, Gao Y, Gong F, Lu G, Lin G^#(2021) The comprehensive variant and phenotypic spectrum of TUBB8 in female infertility. J Assist Reprod Genet 38: 2261-2272

12.Zheng W^*, Hu H^*, Dai J^*, Zhang S, Gu Y, Dai C, Guo J, Xu X, Li Y, Zhang S, Hu L, Gong F, Lu G, Lin G^#(2021) Expanding the genetic and phenotypic spectrum of the subcortical maternal complex genes in recurrent preimplantation embryonic arrest. Clin Genet 99: 286-291

13.Zheng W^*, Zhang S^*, Gu Y, Gong F, Kong L, Lu G, Lin G, Liang B^#, Hu L^#(2021) Non-invasive Metabolomic Profiling of Embryo Culture Medium Using Raman Spectroscopy With Deep Learning Model Predicts the Blastocyst Development Potential of Embryos. Front Physiol 12: 777259

14.Zheng W^*, Chen L, Dai J, Dai C, Guo J, Lu C, Gong F, Lu G, Lin G^#(2020) New biallelic mutations in PADI6 cause recurrent preimplantation embryonic arrest characterized by direct cleavage. J Assist Reprod Genet 37: 205-212