贾相斌，男，博士，助理研究员。2022年博士毕业于中南大学生命科学学院遗传学专业。2025年入职中南大学生命科学学院任讲师，主要研究方向为神经发育疾病的遗传基础和致病机制研究。以第一或通讯作者在J Clin Invest，Sci Adv, Neurosci Bull等杂志发表原创论文。获国家资助博士后研究人员计划B档资助。主持国家自然科学基金青年基金项目，中国博士后科学基金面上项目，湖南省自然科学基金青年基金项目等。

Email:jiaxiangbin@sklmg.edu.cn

主要研究方向

研究方向：神经发育障碍包括孤独症谱系障碍、智力障碍、注意力缺陷与多动障碍等，对社会造成巨大的健康和经济负担且无有效治疗手段。课题组综合利用医学遗传学、分子生物学和神经生物学等手段鉴定孤独症等神经发育障碍的风险基因及其相关致病机制，为神经发育障碍早诊断、早干预提供重要科学依据。

代表论文

1.[1] Peng X#, Jia X#, Wang H, Chen J, Zhang X, Tan S, Duan X, Qiu C, Hu M, Hou H, Parenti I, Kuechler A, Kaiser FJ, Renck A, Caylor R, Skinner C, Peeden J, Cogne B, Isidor B, Mercier S, Nicolas G, Guerrot AM, Faletra F, Musante L, Cohen L, Bergant G, Cuturilo G, Peterlin B, Seeley A, Bachman K, Martinez-Agosto JA, Ravenswaaij-Arts CV, Bos D, Kim KH, Bartolomaeus T, Schmederer Z, Abou Jamra R, Aref-Eshghi Erfan, Zhao W, Zou Y, Hu Z, Pan Q, Li F, Chen G, Li J, Hu Z, Xia K*, Tan J*, Guo H*. Disrupting Integrator complex subunit INTS6 causes neurodevelopmental disorders and impairs neurogenesis and synapse development. J Clin Invest. 2025 Sep 18:e191729. Epub ahead of print.

2.[2] Jia X, Xie W, Du B, He M, Chen J, Chen M, Zhang G, Wang K, Xu W, Liao Y, Tan S, Lyu Y, Yu B, Zheng Z, Sun X, Liao Y, Hu Z, Yuan L, Tan J, Xia K*, Guo H*. Csde1 Mediates Neurogenesis via Post-transcriptional Regulation of the Cell Cycle. Neurosci Bull. 2025 Jun 24. Epub ahead of print.

3.[3] He M#, Du B#, Chen G, Lyu Y, Guo H, Jia X*, Xia K*. Naa15 Haploinsufficiency and De Novo Missense Variants Associate With Neurodevelopmental Disorders and Interfere With Neurogenesis and Neuron Development. Autism Res. 2025 May;18(5):954-965.

4.[4] Jia X#, Zhang S#, Tan S#, Du B, He M, Qin H, Chen J, Duan X, Luo J, Chen F, Ouyang L, Wang J, Chen G, Yu B, Zhang G, Zhang Z, Lyu Y, Huang Y, Jiao J, Chen JYH, Swoboda KJ, Agolini E, Novelli A, Leoni C, Zampino G, Cappuccio G, Brunetti-Pierri N, Gerard B, Ginglinger E, Richer J, McMillan H, White-Brown A, Hoekzema K, Bernier RA, Kurtz-Nelson EC, Earl RK, Meddens C, Alders M, Fuchs M, Caumes R, Brunelle P, Smol T, Kuehl R, Day-Salvatore DL, Monaghan KG, Morrow MM, Eichler EE, Hu Z, Yuan L, Tan J, Xia K*, Shen Y*, Guo H*. De novo variants in genes regulating stress granule assembly associate with neurodevelopmental disorders. Sci Adv. 2022 Aug 19;8(33):eabo7112.

5.[5] Wegler M, Jia X, Alders M, Bouman A, Chen J, Duan X, Lauzon JL, Mathijssen IB, Sticht H, Syrbe S, Tan S, Guo H, Abou Jamra R. De novo variants in the PABP domain of PABPC1 lead to developmental delay. Genet Med. 2022 Aug;24(8):1761-1773.