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谭洁琼
邮  箱: tanjieqiong@sklmg.edu.cn
职  称:
副教授
联系电话: 0731-84805340
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个人简历

谭洁琼,男,博士,副研究员,1980年9月出生。2011年获得中南大学医学遗传学国家重点实验室细胞生物学博士学位;2013-2015年哈佛医学院波士顿儿童医院神经生物系从事博士后研究。现研究方向为神经退行性疾病的发生机制。

主持国家自然科学青年基金、博士点新教师基金和湖南省自然基金;参与包括973项目、国家自然科学基金面上项目、重点项目等在内的各级科研项目6项;在J Biol Chem、Autophagy等杂志上发表SCI论文20篇。

发表文章

1.Luo X., Cheng W., Wang SH., Chen Z*., Tan J*. Autophagy Suppresses Invasiveness of Endometrial Cells through Reduction of Fascin-1. BioMed Research International Volume 2018 in press.

2.Qin L.#,Tan J.#, Zhang H., Kousar Rizwana, Lu J., Tang J., Jiang B., Shen X., Guo J, Tang B., Tan L, Wang C*, BAG5 interacts with DJ-1 and inhibits the neuroprotective effects of DJ-1 to combat mitochondrial oxidative damage, Oxidative Medicine and Cellular Longevity,2017, 2017:5094934.

3.Zhang, Y. #,Tan, J.#, Long, M., Yang, H., Yuan, S., Tang, A., Chang, S., and Hu, Y. An emerging dual collaborative strategy for high-performance tumor therapy with mesoporous silica nanotubes loaded with Mn3O4. J. Mater. Chem. B 2016,4, 7406-7414

4.Tan J#., Zhang T., Jiang L., Chi J., Hu D., Pan Q., Wang D., Zhang Z*. Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein. The Journal of biological chemistry, 2011, 286:29654-62

5.Liu M#, Qin L#, Wang L,Tan J, Zhang H, Tang J, Shen X, Tan L, Wang C*. α‑synuclein induces apoptosis of astrocytes by causing dysfunction of the endoplasmic reticulum‑Golgi compartment. Mol Med Rep. 2018 May 9.

6.Zou Y#, He W, Wang K, Han H, Xiao T, Chen X, Zhou B,Tan J, Xia K, Tang B, Chen C, Shen L, Yan R*, Zhang Z*. Identification of rare RTN3 variants in Alzheimer's disease in Han Chinese.Hum Genet. 2018 Feb;137(2):141-150.

7. Tang C#, Han H, Yan M, Zhu S, Liu J, Liu Z, He L,Tan J, Liu Y, Liu H, Sun L, Duan S, Peng Y, Liu F, Yin XM, Zhang Z, Dong Z*. PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury.Autophagy. 2018 Feb 17:1-18.

8.Chen T#,Tan J, Wan Z, Zou Y, Afewerky HK, Zhang Z, Zhang T*. Effects of Commonly Used Pesticides in China on the Mitochondria and Ubiquitin-Proteasome System in Parkinson's Disease.Int J Mol Sci. 2017 Nov 23;18(12).

9.Zheng Q#, Huang C, Guo J,Tan J, Wang C, Tang B, Zhang H*. Hsp70 participates in PINK1-mediated mitophagy by regulating the stability of PINK1. Neurosci Lett. 2018 Jan 1;662:264-270.

10.Wang SF, Liu LF, Wu MY, Cai CZ, Su H,Tan J, Lu JH, Li M*. Baicalein prevents 6-OHDA/ascorbic acid-induced calcium-dependent dopaminergic neuronal cell death.Sci Rep. 2017 Aug 21;7(1):8398.

11.Zhang J#, Lei H, Chen Y, Ma YT, Jiang F,Tan J, Zhang Y, Li JD*. Enzymatic O-GlcNAcylation of α-synuclein reduces aggregation and increases SDS-resistant soluble oligomers. Neurosci Lett. 2017 Aug 10;655:90-94.

12.Zhang T.#, Xue L., Li L., Tang C., Wan Z., Wang R.,Tan J.,Tan Y., Han H., Tian R., Billiar T. R., Tao W. A., Zhang Z*. BNIP3 Suppresses PINK1 Proteolytic Cleavage to Promote Mitophagy. The Journal of biological chemistry, 2016,

13.Park G. #,Tan J.,Garcia G., Kang Y., Salvesen G., Zhang Z*. Regulation of Histone Acetylation by Autophagy in Parkinson Disease. The Journal of biological chemistry, 2016, 291:3531-40

14.Zhong B#., Hu Z.,Tan J.,Lu T., Lei Q., Chen C., Zeng L*. Hsp20 Protects against Oxygen-Glucose Deprivation/Reperfusion-Induced Golgi Fragmentation and Apoptosis through Fas/FasL Pathway. Oxid Med Cell Longev, 2015, 2015:606934

15.Wang X. #, Guo J., Fei E., Mu Y., He S., Che X.,Tan J.,Xia K., Zhang Z.*, Wang G., Tang B. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PloS one, 2014, 9:e86276

16.Zeng L. #,Tan J.,Lu W., Lu T., Hu Z.* The potential role of small heat shock proteins in mitochondria. Cellularsignalling, 2013, 25:2312-9

17.Zeng L.#,Tan J.,Lu W., Hu Z*. Blockade of Ser16-Hsp20 phosphorylation attenuates neuroprotection dependent upon Bcl-2 and Bax. Curr Neurovasc Res, 2013, 10:208-15

18.Lu J. H#.,Tan J. ,Durairajan S. S., Liu L. F., Zhang Z. H., Ma L., Shen H. M., Chan H. Y.*, Li M.* Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy, 2012, 8:98-108