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副高
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邓梅春
邮  箱: dengmch@csu.edu.cn
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副教授
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个人简历

2010年于湖南师范大学蛋白质化学与发育生物学教育部重点实验室博士毕业,于2011年进入中南大学生命科学学院工作。长期从事动物活性多肽的结构与功能研究领域,主持或参与国家自然科学基金和国家973计划资助项目等10余项,包括主持国家自然科学基金、中国博士后科学基金、湖南省博士后基金、中央高校青年教师助推基金等。在Cell Mol Life SciNeuropharmacologyEur J Pharmacol等国际著名杂志发表SCI论文20余篇。目前申请国家发明专利3项,授权1项,获湖南省自然科学科学论文二等奖湖南师范大学优秀博士论文奖等。


研究方向

 1、天然活性多肽的神经药理学及药效学

 2、天然活性抗癌及抗菌肽的药效学及机制研究

 3、疾病发生与细胞膜受体的关系

代表论文:

1. Deng M*, Hu Z, Cai T, Liu K, Wu W, Luo X, Jiang L, Wang M, Yang J, Xiao Y, Liang S. Characterization of ion channels on subesophageal ganglion neurons from Chinese tarantula Ornithoctonus huwena: Exploring the myth of the spider insensitive to its venom. Toxicon, 2016,120:61-8.

2. Tao H1, Chen X1, Deng M1, Xiao Y, Wu Y, Liu Z, Zhou S, He Y, Liang S. Interaction site for the inhibition of tarantula Jingzhaotoxin-XI on voltage-gated potassium channel Kv2.1. Toxicon, 2016,124:8-14.

3. Deng M*, Luo X, Xiao Y, Sun Z, Jiang L, Liu Z, Zeng X, Chen H, Tang J, Zeng W, Liang S*. Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonus huwena.Neuropharmacology, 2014,79: 657-67.

4. Deng M*, Luo X, Jiang L, Chen H, Wang J, He H, Liang S*. Synthesis and biological characterization of synthetic analogs of Huwentoxin-IV (Mu-theraphotoxin-Hh2a), a neuronal tetrodotoxin-sensitive sodium channel inhibitor. Toxicon, 2013,71: 57-65.

5. Deng M, Kuang F, Sun Z, Tao H, Cai T, Zhong L, Xiao Y*, Liang S*. Jingzhaotoxin-IX, a novel gating modifier of both sodium and potassium channels from Chinese tarantula Chilobrachys jingzhao. Neuropharmacology, 2009, 57: 77-87.

6. Chen J1,Deng M1, He Q1, Meng E, Jiang L, Liao Z, Rong M, Liang S*. Molecular diversity and evolution of cystine knot toxins of the tarantulaChilobrachys jingzhao. Cell Mol Life Sci, 2008, 65:2431-2444. (1co-first author)

7. Deng M, Luo X, Meng E, Xiao Y, Liang S*. Inhibition of insect calcium channels by huwentoxin-V, a neurotoxin from Chinese tarantulaOrnithoctonus huwenavenom. Eur J Pharmacol, 2008, 582:12-16.

8.  Liu Z, Cai T, Zhu Q, Deng M, Li J, Zhou X, Zhang F, Li D, Liu Y, Hu W, Liang S*. Structure and function ofhainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana. J Biol Chem, 2013,288:20392-403.

9. Tao H, Wu Y, Deng M, He J, Wang M, Xiao Y, Liang S*. Molecular determinants for the tarantula toxin jingzhaotoxin-I interacting with potassium channel Kv2.1. Toxicon, 2013,63:129-36.

10. Jiang L, Liu C, Duan Z, Deng M, Tang X, Liang S*. Transcriptome analysis of venom glands from a single fishing spiderDolomedes mizhoanus. Toxicon, 2013,73:23-32.