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副高
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虢毅
邮  箱: yiguo@csu.edu.cn
职  称:
副教授
联系电话: 0731-82650240
传  真:
地  址: 湖南省长沙市桐梓坡路172号 生命科学学院生物医学信息学系
个人简历

教育经历

2009.09-2012.12 中南大学  博士

2000.09-2002.06 中南大学 硕士

1994.09-1998.06 湖南大学 学士


工作经历

2013.09-至今     中南大学 副教授

2005.01-2007.08    美国MD安德森癌症中心助理研究员

2003.09-2013.08   中南大学 讲师

1998.7-2003.08    中南大学 助教


行政职务

信息检索教研室副主任


学术奖励

湖南省精品在线开放课程《医学文献检索》主讲教师(排名第三)2018

国家精品课程《文献信息检索》主讲教师((排名第四),2009


研究方向

遗传性疾病的基因定位、基因克隆、致病位点鉴定、易感基因筛选和生物信息学研究


代表性论文:

1. Yi Guo, Peng Wang, Xiaorong Li, Shaihong Zhu, Hongbo Xu, Shizhou Li, Hao Deng, Lamei Yuan. Identifying a BRCA2 p. L1908RfsX2 mutation in a Han-Chinese family with breast cancer. Bioscience Reports. 2019;39(4).pii: BSR20182471.

2. Mingyuan Wang#, Yi Guo#, Pengfei Rong, Hongbo Xu, Lina Gong, Hao Deng, Lamei Yuan*. COL1A2 p.Gly1066Val mutation identified in a Chinese family with osteogenesis imperfecta type I. Molecular Genetics & Genomic Medicine. 2019;7(5):e619.  

3. Heng Xiao#, Yi Guo#, Junhui Yi, Hong Xia, Hongbo Xu, Lamei Yuan, Pengzhi Hu, Zhijian Yang, Zhenghao He, Hongwei Lu, Hao Deng, Identification of a novel keratin 9 missense mutation in a Chinese family with epidermolytic palmoplantar keratoderma, Cell Physiol Biochem, 2018, 46(5): 1919-1929  

4. Peng Wang#, Yi Guo#, Chengyuan Song, Yiming Liu, Hao Deng, PINK1 p.K520RfsX3 Mutation Identified in a Chinese Family with Early-onset Parkinson’s disease, Neurosci Lett, 2018, 676:98-102

5. Hao Deng, Ting Tan, Quanyong He, Qiongfen Lin, Zhijian Yang, Anding Zhu, Liping Guan, Jinjing Xiao, Zhi Song, Yi Guo*, Identification of a missense HOXD13 mutation in a Chinese family with syndactyly type I-c using exome sequencing, Molecular Medicine Reports, 2017, 16:473-477  

6. Yi Guo, Ting Tan, Xiong Deng, Zhi Song, Zhijian Yang, Yan Yang, Hao Deng, TCEANC2 rs10788972 and rs12046178 variants in the PARK10 region in Chinese Han patients with sporadic Parkinson's disease, Neurobiology of Aging, 2015, 36(12): 3335.e1-2

7. Yi Guo, Jinzhong Yuan, Hui Liang, Jingjing Xiao, Hongbo Xu, Lamei Yuan, Kai Gao, Bin Wu, Yongchang Tang, Xiaorong Li, Hao Deng, Identification of a novel COL4A5 mutation in a Chinese family with X-linked Alport syndrome using exome sequencing, Molecular Biology Reports, 2014, 41: 3631-3635    

8. Yi Guo, Zhi Song , Hongbo Xu, Junhui Yi, Wen Zheng, Hong Xiang, Xiong Deng, Hongwei Lv, Kai Gao, Yong Qi, Hao Deng, Heterogeneous phenotype in a family with the FERM domain-containing 7 gene R335X mutation, Can J Ophthalmol, 2014, 49(1): 50-53